June 1, 2022
By Luke Seesink, B.Applied Science, Senior Clinical Research Manager, Brien Holden Vision Institute
Defocus incorporated multiple segments (DIMS) spectacle lenses have been used to induce myopic defocus in the peripheral retina as an intervention to stop or slow myopic progression in children.
This three-year follow-up study followed 128 Chinese children who had either worn DIMS spectacle lenses after a period of single vision (SV) lens wear (n=55) or a period of continued DIMS lens wear (n=65). Cycloplegic spherical equivalent refraction (SER) and axial length (AL) were measured at six-month intervals.
The change in SER and AL in the two groups was not statistically significant in the third year. The researchers suggest that DIMS wear successfully controls myopic progression irrespective of wearing them for one or three years. The change in myopia in both groups was significantly less than in the historical control group. The researchers plan to follow up on those participants who discontinued DIMS wear to see if a rebound in myopia progression occurred.
Myopia Control Effect of Defocus Incorporated Multiple Segments (DIMS) Spectacle Lens in Chinese Children: Results of a 3-Year Follow-Up Study
Carly SY Lam, Wing Chun Tang, Paul H Lee, Han Yu Zhang, Hua Qi, Keigo Hasegawa, Chi Ho To
Aims: To determine myopia progression in children who continued to wear the defocus incorporated multiple segments (DIMS) lenses or switched from single vision (SV) to DIMS lenses for a 1- year period following a 2-year myopia control trial.
Methods: 128 children participated in this study. The children who had worn DIMS lenses continued to wear DIMS lenses (DIMS group), and children who had worn SV lenses switched to wear DIMS lenses (Control- to- DIMS group). Cycloplegic spherical equivalent refraction (SER) and axial length (AL) were measured at a 6-month interval. Historical controls were age-matched to the DIMS group at 24 months and used for comparing the third-year changes.
Results: Over 3 years, SER and AL changes in the DIMS group (n=65) were −0.52±0.69D and 0.31±0.26 mm; these changes were not statistically significant over time (repeated measures analysis of variance, p>0.05). SER (−0.04±0. 38D) and AL (0.08±0.12 mm) changes in the Control- to- DIMS group (n=55) in the third year were less compared with the first (mean difference=0.45 ± 0.30D, 0.21±0.11 mm, p<0.001) and second (0.34±0.30D, 0.12±0.10 mm, p<0.001) years. Changes in SER and AL in both groups over that period were significantly less than in the historical control group (DIMS vs. historical control: mean difference=−0.18±0.42D, p=0.012; 0.08±0.15 mm, p=0.001; Control- to- DIMS versus historical control: adjusted mean differences=−0.30±0.42D, p<0.001; 0.12±0.16 mm, p<0.001).
Conclusions: Myopia control effect was sustained in the third year in children who had used the DIMS spectacles in the previous 2 years and was also shown in the children switching from SV to DIMS lenses.
Lam, C. S., Tang, W. C., Lee, P. H., Zhang, H. Y., Qi, H., Hasegawa, K., & To, C. H. (2021). Myopia control effect of defocus incorporated multiple segments (DIMS) spectacle lens in Chinese children: results of a 3-year follow-up study. British Journal of Ophthalmology.
|Luke Seesink is a Senior Clinical Research Manager at the Brien Holden Vision Institute. He has first-class honors from a B.Applied Science (Orthoptics) degree at the University of Sydney. He has worked for almost 20 years as a qualified orthoptist and in different clinical research roles within ophthalmology.|