August 15, 2019
Five-year data from the world’s longest-running clinical trial of pediatric contact lens wear is offering new myopia management insights for eye care professionals. CooperVision’s latest report from its landmark MiSight® 1 day study1,2 comes as optometrists, ophthalmologists and public health authorities are facing the growing severity and prevalence of progressive childhood myopia.
Myopia—also known as nearsightedness and short-sightedness—is projected to affect the vision and increase risks to ocular health of approximately five billion people by 2050, more than doubling today’s numbers3. CooperVision researchers were among the first to seek well-tolerated and effective methods to limit myopia progression. From those efforts came MiSight® 1 day, the first soft contact lens specifically designed to slow myopia progression in children.
Part one of the study quantified three-year effectiveness of the innovative MiSight 1 day lens versus an equivalent single vision 1-day lens in slowing the rate of progression of juvenile-onset myopia. The peer-reviewed “A 3-Year Randomized Clinical Trial of MiSight Lenses for Myopia Control” is now available in pre-publication format from Optometry and Vision Science4.
Part two was initiated at the 36-month mark, when children in the original control group were refit with MiSight® 1 day. They continued to be tracked separately to compare the rate of myopia progression between the two matched populations with different treatment history.
The latest data reveals that:
- Progression rates among the original control group—after already showing a dramatic reduction in year four following refitting—matched the children who had been wearing MiSight® 1 day for the entire duration of the study in spherical equivalent refractive error (0.17D) and axial length (0.07mm) during year five.
- Vision performance remained excellent among both groups, with visual acuity of better than 20/20 [6/6] at every scheduled appointment, with no significant differences across groups or visits.
Furthermore, there were minimal adverse events, and none of the children wearing the daily disposable contact lenses in both groups presented at greater than grade 2 for all typical anterior eye clinical observations.
“The mirrored slowed progression across both groups suggests that myopia progression with MiSight® 1 day lenses is more dependent on age of the patient than their baseline myopia or length of time under treatment,” said Paul Chamberlain, Director of Research Programs for CooperVision. “The children more recently entering treatment are progressing at the same rate as those completing their fifth year of MiSight® wear. This information can help practitioners as they consider treating slightly older kids than studied in part one of the trial.”
“The data and insights from this multi-year clinical trial are powerful, reinforcing the positive impact of this lens on myopic children,” said Daniel McBride, President of CooperVision. “Our dedication to helping eye care professionals address the pediatric myopia epidemic is unwavering, demonstrated through research, education and distinctive offerings such as MiSight® 1 day.”
No other prospective randomized controlled study has offered conclusive data for such a high degree of continued efficacy in myopia management using a 1-day soft contact lens over five years. Physiological changes among 108 myopic children from Singapore, Canada, England, and Portugal were evaluated during the latest reported period.
Presentation of the five-year data and continued research are part of a series of far-reaching initiatives by CooperVision to educate eye care professionals and aligned healthcare practitioners about advances in myopia management, including widespread conference participation, study support, clinical training events and more.
In June, a trio of myopia management visionaries were honored with the prestigious 2019 British Contact Lens Association (BCLA) Industry Award for their work developing, researching and commercializing MiSight® 1 day. John Phillips, Stuart Cockerill and Paul Chamberlain were selected from a field of finalists who have all made immeasurable contributions to the field.
# # #
1 MiSight® 1 day contact lenses are currently available for sale in Canada, the United Kingdom, France, Spain, Portugal, Netherlands, Belgium, Germany, Austria, Switzerland, the Nordic Region, Singapore, Malaysia, Hong Kong, Australia and New Zealand. MiSight® 1 day is not approved in the United States.
2 Chamberlain P, Logan N, Jones D, Gonzalez-Meijome J, Saw S-M, Young G. Clinical evaluation of a dual-focus myopia control 1 day soft contact lens: 5-year results (2019 BCLA Clinical Conference & Exhibition).
3 Holden et al, – Global Prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology 2016. 123(5):1036-1042
4 Chamberlain P, Peixoto-de-Matos Logan N, Ngo C, Jones D, Young G. A 3-Year Randomized Clinical Trial of MiSight Lenses for Myopia Control. Optometry and Vision Science. July 19, 2019 – Volume Pre-Publication – Issue – p